Table 4.
FBC index of nanoparticles in combination with antimicrobial agents against Staphylococcus aureus Xen 30
| Tested antibiotics | FBC index | MRSA Xen 30
|
Interpretation – 1/2/3 | ||
|---|---|---|---|---|---|
| Combination with
| |||||
| 1 – MNP@NH2 | 2 – MNP@Au | 3 – MNP@PQAS | |||
| LL-37 | FBC index | 2 | 0.0625 | 0.5 | I/S/PS |
| CSA-13 | FBC index | 1 | 0.5 | 1 | AD/PS/AD |
| CSA-131 | FBC index | 1 | 1 | 1 | AD/AD/AD |
| VAN | FBC index | 0.53 | 1 | 0.13 | PS/AD/S |
Notes: FBC values >4 indicate antagonistic effects (AN), values between 4 and 1.01 indicate indifference (I), values between 1 and 0.76 indicate additive effects (AD), and values <0.76–0.5 indicate partial synergy (PS) and <0.5 indicate a synergistic effect (S).
Abbreviations: FBC, fractional bactericidal concentration; MRSA, methicillin-resistant S. aureus; MNP, magnetic nanoparticle; PQAS, poly(quaternary ammonium salts); CSA, cationic steroid antibiotic; VAN, vancomycin; LL-37, cathelicidine LL-37.