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. 2016 Oct 18;11:5415–5427. doi: 10.2147/IJN.S111950

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© 2016 Chen et al. This work is published and licensed by Dove Medical Press Limited

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Flow cytometry measurement of the intracellular uptake of free DOX, HTM, and PHTM in MCF-7 cells (A) and MDA-MB-231 cells (B) and the fluorescence intensity of DOX accumulation at 4 hours in MCF-7 cells (C) and MDA-MB-231 cells (D), respectively.

Notes: ^*P<0.05. Data expressed as mean ± standard deviation (n=3).

Abbreviations: DOX, doxorubicin; HA, hyaluronic acid; HTM, HA-PHis/TPGS2k mixed micelles; NS, not significant; pep-TPGS2k, Her2 peptide-modified TPGS2k; PHis, poly(L-histidine); PHTM, HA-PHis/pep-TPGS2k mixed micelles; TPGS2k, d-α-tocopheryl polyethylene glycol 2000.