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. 2016 Oct 18;11:5415–5427. doi: 10.2147/IJN.S111950

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© 2016 Chen et al. This work is published and licensed by Dove Medical Press Limited

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(A) The tumor volume and (B) body weight changes of saline, DOX solution, HTM, and PHTM on the MDA-MB-231 tumor-bearing mice; (C) the images of excised tumor tissues; and (D) the tumor weight of different formulation from MDA-MB-231 tumor-bearing mice at the time of sacrifice.

Notes: Data expressed as mean ± standard deviation (n=5). *P<0.05.

Abbreviations: DOX, doxorubicin; HA, hyaluronic acid; HTM, HA-PHis/TPGS2k mixed micelles; pep-TPGS2k, Her2 peptide-modified TPGS2k; PHis, poly(L-histidine); PHTM, HA-PHis/pep-TPGS2k mixed micelles; TPGS2k, d-α-tocopheryl polyethylene glycol 2000.