FIGURE 7.

mNT deficiency increases Fgf15 synthesis and ameliorates perturbation of hepatic bile acid homeostasis in ethanol (E)-fed mice. Wild-type (WT) or mNTKO (KO) mice were pair-fed either a control diet or an ethanol-containing diet for 4 weeks. A, relative ileum mRNA levels of Fgf15. B, relative liver mRNA levels of Cyp7a1, Cyp27a1, and Cyp8a1. C, serum total of bile acids. D, total liver bile acids. Results are expressed as mean ± S.E. (n = 5–9 mice). Means without a common letter differ, p < 0.05.