FIGURE 9.

mNT deficiency activates hepatic Sirt1 and attenuates NF-κB activity in ethanol-administered mice. Wild-type (WT) or mNTKO (KO) mice were pair-fed either a control diet or an ethanol (E)-containing diet for 4 weeks. A, representative Western analysis of liver Sirt1, Ac-NF-κB, NF-κB. B, relative liver protein levels of Sirt1, acetylated (Ac)-NF-κB, NF-κB. C, relative liver mRNA levels of Cd36, PPARα, and Mcad. D, relative serum β-hydroxybutyrate levels. Results are expressed as mean ± S.E. (n = 4–9 mice). Means without a common letter differ, p < 0.05.