TABLE 4.
Statistics of the prevalence of E35D natural polymorphisms, where numbers in parentheses indicate the total number of isolates in analysis (one mutation was extracted from one person)
The data analysis is up to March 2015. – indicates no data available in the database.
| E35D mutation in HIV-1 PR subtypes with/without treatment | ||||||||
|---|---|---|---|---|---|---|---|---|
| B | C | D | AG | G | A | AE | F | |
| Naive | 30.2% (29,287) | 25.4% (10,322) | 22.4% (1,976) | 25.1% (4,237) | 49.6% (1665) | 91.8% (4,993) | 83.7% (6,152) | 91% (1,103) |
| TPV | 48.9% (94) | – | 100% (1) | 50% (2) | – | 100% (2) | – | 66.6% (3) |
| APV | 37.8% (193) | 66.6% (3) | – | 0% (1) | 100% (1) | – | – | 100% (5) |
| RTV | 33.4% (1,069) | 28.5% (28) | 46.1% (13) | 14.2% (7) | 66.6% (15) | 87.5% (8) | 88.8% (9) | 90.7% (54) |
| NFV | 32.4% (824) | 37.5% (16) | 50% (6) | 33.3% (3) | 75% (8) | 100% (2) | 100% (1) | 94.1% (51) |
| SQV | 32.6% (925) | 34.7% (23) | 33.3% (9) | 0% (3) | 63.6% (11) | 83.3% (6) | 88.8% (9) | 96.9% (33) |
| IDV | 28.9% (1,852) | 25.9% (54) | 40.0% (25) | 15.2% (46) | 89.2% (84) | 89.1% (37) | 96.4% (28) | 94.2% (105) |
| LPV | 23.1% (320) | 50% (8) | 0% (1) | 0% (2) | 33.3% (9) | 85.7% (14) | 100% (1) | 72.7% (11) |
| DRV | 0% (45) | – | – | – | – | – | – | – |