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Motor function and dopaminergic neuronal loss due to MPTP. (a) MPTP exposure led to a significant reduction in the forepaw grip strength and (b) four-limb hanging duration at 8th day from the start of MPTP treatment. (c) Tyrosine hydroxylase immunostaining results depicting severe loss of dopaminergic neurons in the substantia nigra pars compacta and (d) striatum following the treatment with MPTP in mice (bottom).
