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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Exp Neurol. 2016 Jun 21;285(Pt B):110–125. doi: 10.1016/j.expneurol.2016.06.021

Figure 12.

Figure 12

Effects of a neurokinin (NK)-1 receptor antagonist (RA), netupitant, on micturition reflex function from open outlet, continuous fill cystometry in NGF-OE mice and littermate WT mice at postnatal (P) day 7, P14, P28 and Adult (A). Intravesical netupitant (0.1 μg/ml) significantly (p ≤ 0.01) increased voided volume (A) and intercontraction interval (ICI) (B) in NGF-OE mice at all postnatal ages examined. Intravesical netupitant (0.1 μg/ml) was without effect on voided volume (A) or ICI (B) in WT mice except at P14 where there was a significant (p ≤ 0.01) increase in voided volume. *, p ≤ 0.01 compared to vehicle. Values are means ± S.E.M. (n = 6–8 for each group).