Figure 9.
Semi-quantitative analyses of neurochemistry in urothelium of NGF-OE mice at various postnatal ages (P7, P14, P21, P28, A). Histograms of neurochemical expression in the urothelium during postnatal development expressed as a percentage of expression above threshold and averaged for all bladders from specific postnatal ages for NGF-OE and WT mice. Values are means ± S.E.M. (n = 6–8 for each group). At each postnatal age examined (P7, P14, P21, P28, Adult (A)), the percent expression of Protein Gene Produce (PGP)9.5 (A), Substance P (Sub P) (B), neurofilament (NF200) (C) and calcitonin gene-related peptide (CGRP) (D) was significantly (*p ≤ 0.01) above threshold in NGF-OE vs. WT mice. No changes were observed for tyrosine hydroxylase expression in NGF-OE vs. WT mice at any age examined (E).