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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Laryngoscope. 2016 Jun 14;126(11):E356–E361. doi: 10.1002/lary.26098

Figure 1. iSGS Anatomic, Physiologic and Histologic characteristics.

Figure 1

Trichome blue staining of iSGS subglottic scar demonstrating extensive blue collagen staining and an intact basement membrane (Magnification 20x, scale bar = 100μM) (A.). Sirius red staining highlights subepithelial collagen deposition in red (Magnification 40x, scale bar = 100μM) (B.). Transmission electron microscopy shows irregular, disordered subepithelial collagen bundles (C.), as well as abundant fibroblasts (D.). qPCR from 10 iSGS patients for extracellular matrix constituents (Types I & III collagen, Fibronectin) from iSGS scar compared with 23 healthy controls (E.), asterisk indicates statistical significance (Two-tailed, Mann Whitney test; p<0.05).