Table 5. Univariate and multivariate analyses of factors associated with PFS in patients with LD.
| Variable | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| Hazard ratio | 95% Hazard ratio | p-value | Hazard ratio | 95% Hazard ratio | p-value | |
| Age (≤65 yr) | 0.856 | 0.624–1.175 | 0.337 | - | - | - |
| BMI (>23) | 0.951 | 0.693–1.304 | 0.754 | - | - | - |
| ECOG PS (2) | 0.816 | 0.452–1.473 | 0.500 | - | - | - |
| Smoking (current or Ex) | 0.565 | 0.373–0.855 | 0.007 | 0.612 | 0.395–0.948 | 0.028 |
| PY | 1.003 | 0.996–1.011 | 0.339 | - | - | - |
| DM (+) | 1.084 | 0.693–1.695 | 0.725 | - | - | - |
| HF (+) | 0.000 | 0.000 | 0.982 | - | - | - |
| LC (+) | 1.607 | 0.224–11.542 | 0.637 | - | - | - |
| CVA (+) | 0.544 | 0.201–1.471 | 0.230 | - | - | - |
| Inactive TB (+) | 0.987 | 0.558–1.747 | 0.965 | - | - | - |
| The sums of cycles | - | |||||
| 3 | 0.227 | 0.075–0.684 | 0.008 | 0.827 | 0.269–2.54 | 0.74 |
| ≥4 | 0.161 | 0.072–0.360 | <0.001 | 0.15 | <0.001 | |
| CCRT (yes) | 2.531 | 1.237–5.179 | 0.011 | 4.605 | 1.913–11.084 | 0.001 |
| PCI (yes) | 0.749 | 0.543–1.034 | 0.079 | 0.683 | 0.486–0.96 | 0.028 |
| First CTx regimen (EP) | 1.208 | 0.669–2.178 | 0.531 | - | - | - |
progression-free survival; LD: limited disease; BMI: body mass index; ECOG PS: Eastern Cooperative Oncology Group performance status; Ex: stop smoking now; PY: pack years; DM: diabetes mellitus; HF: heart failure; LC: liver cirrhosis; CVA: cerebrovascular disease; TB: tuberculosis; CCRT: concurrent chemoradiotherapy; PCI: prophylactic cranial irradiation; CTx: chemotherapy; EP: etoposide-carboplatin.