Table 1. The demographic and clinical characteristics of the ADNI subjects at baseline.
| Characteristics | CN group | MCI group | AD group | P-valueb | |||
|---|---|---|---|---|---|---|---|
| Age (years) | 281 | 74.51±5.56 | 483 | 72.28±7.45 | 48 | 75.51±9.23 | - |
| Gender (male/female) | 281 | 136/145 | 483 | 282/201 | 48 | 30/18 | - |
| Education (years) | 281 | 16.41±2.66 | 483 | 15.98±2.82 | 48 | 15.73±2.62 | 0.08 |
| ApoE ε4 (0/1/2) | 281 | 204/70/7 | 483 | 262/180/41 | 48 | 14/25/9 | <0.01 |
| CDRSB (scores) | 207 | 6.54±0.55 | 406 | 6.32±0.64 | 47 | 5.3±0.72 | <0.01 |
| ADAS (scores) | 281 | 29.07±1.15 | 483 | 27.89±1.69 | 48 | 22.96±2.03 | <0.01 |
| MMSE (scores) | 281 | 9.06±4.23 | 480 | 15.3±6.65 | 48 | 29.8±8.44 | <0.01 |
| RAVLT total (scores) | 280 | 44.83±9.6 | 483 | 36.16±10.86 | 47 | 22.32±7.84 | <0.01 |
| FAQ (scores) | 281 | 0.17±0.66 | 481 | 2.85±3.99 | 48 | 12.6±7.14 | <0.01 |
| Hippocampus (mm3) | 257 | 7344±895 | 422 | 6996±1126 | 39 | 5757±948 | <0.01 |
| Middle Temporal (mm3) | 257 | 20298±2600 | 422 | 20186±2735 | 39 | 17776±3230 | <0.01 |
| Entorhinal (mm3) | 257 | 3803±650 | 422 | 3610±723 | 39 | 2919±705 | <0.01 |
| FDG | 207 | 6.55±0.55 | 406 | 6.32±0.64 | 47 | 5.3±0.72 | <0.01 |
Abbreviation: CN, cognitively normal; MCI, mild cognition impairment; AD, Alzheimer's disease; CDRSB, Clinical Dementia Rating scale sum of boxes; ADAS, Alzheimer's disease Assessment Scale; MMSE, Mini-Mental State Exam; RAVLT, Rey Auditory Verbal Learning Test; FAQ, Functional Activities Questionnaire; FDG, Cerebral Glucose Metabolism Rate measured with fluorodeoxyglucose-positron emission tomography(FDG-PET). *P values for continuous variables are from one-way analysis of variance (ANOVA). P values for categorical data are from chi square test. Data are given as mean ± standard deviation unless otherwise indicate.