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. 2016 Feb 17;7(22):31892–31906. doi: 10.18632/oncotarget.7441

Figure 8. IKKβ inhibitor, CmpdA sensitizes O28 cells to cisplatin-induced apoptosis.

Figure 8

A. Cells were treated with DMSO, CmpdA, cisplatin or CmpdA plus cisplatin for 48 hours and caspase activity was measured. The experiments were performed in triplicate, and the results are representative of three independent experiments (# P < 0.05, compared to CDDP treatment; *P < 0.05, compared to DMSO control or CmpdA treatment). B. Cells were treated as A for 48 hours and caspase-3 cleavage was determined by western blot. The experiments were repeated three times. C. Cells were treated with CompA, Cisplatin, or CompA and Cisplatin as indicated and colony formation was observed 10 days after treatment. Each experiment was repeated three times (### P < 0.001, compared to CDDP treatment; **P < 0.01, ***P < 0.001, compared to DMSO control or CmpdA treatment).