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. 2016 Apr 1;7(22):32100–32112. doi: 10.18632/oncotarget.8527

Figure 1. LOX activity increases in human PDAC.

Figure 1

(A) Summary of studies comparing levels of LOX, LOXL1, LOXL2, LOXL3, and LOXL4 transcripts in PDAC versus normal-tissue counterparts, obtained using the Oncomine database with the following settings: threshold P-value: 0.05; fold change: 1.5; gene rank all. The number indicated the number of study showing the same differential. Red color indicated an increase in the tumor whereas blue color indicated a decrease. (B–C) RNAs were extracted from both pancreatic normal and tumor tissues from the same patients and LOX, LOXL1, LOXL2, LOXL3, and LOXL4 transcript levels were assayed by qRT-PCR and normalized against HPRT1. LOXL3 was not detected. (B) Results are presented for each patient. (C) Results are presented as means ± SEM of LOX, LOXL1, LOXL2, and LOXL4 induction. P-values were determined with the Mann-Whitney U test.