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. 2016 Mar 31;7(22):32221–32231. doi: 10.18632/oncotarget.8515

Figure 2. Integrin β1 knockdown and mTOR inhibitor reverse higher matrix stiffness-mediated HCC stemness characteristics.

Figure 2

A. The proportion of cells with CD133(+) or EpCAM(+) all decrease in the transfected HCC cells with LV-ITGB1-RNAi under higher stiffness stimulation. B. Oxaliplatin resistance analysis shows that higher stiffness-induced HCC cells with LV-ITGB1-RNAi present higher proportion of early and late apoptosis as compared with that of the controls. C. and D. The number of spheres derived from higher stiffness-induced HCC cells treated with LV-ITGB1-RNAi and Rapamycin also significantly diminish. Error bars indicate SEM, ***, P value < 0.001; **, P value< 0.01; *, P value< 0.05.