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Expression of miR-K3 downregulates NFIB, MYB, C/EBPα and Ets-1, which activates the promoter activity of KSHV immediate-early (IE) gene, Rta, resulting in inhibition of viral lytic replication. miR-K3 also directly targets GRK2 promoting cell migration and invasion, and KSHV latency and angiogenesis by activating the CXCR2/AKT pathway.
