Table 1. Correlation of E6 with miR-184 and Bcl-2 expression and the relationship between miR- 184 and Bcl-2 mRNA levels in tumor tissues from NSCLC patients.
| Variable | Case No. (n = 136) | E6 expression | P value | miR-184 | P value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Negative (%) | Positive (%) | Low (%) | High (%) | ||||||||
| 79 | (58.1) | 57 | (41.9) | 68 | (50.0) | 68 | (50.0) | ||||
| Bcl-2 mRNA | |||||||||||
| Low | 68 | 45 | (66.2) | 23 | (33.8) | 0.056 | 28 | (41.2) | 40 | (58.8) | 0.040 |
| High | 68 | 34 | (50.0) | 34 | (50.0) | 40 | (58.8) | 28 | (41.2) | ||
| miR-184 | |||||||||||
| Low | 68 | 31 | (39.2) | 37 | (64.9) | 0.003 | |||||
| High | 68 | 48 | (60.8) | 20 | (35.1) | ||||||
| p53 mutation | |||||||||||
| No | 97 | 50 | (51.5) | 47 | (48.5) | 0.569 | |||||
| Yes | 39 | 18 | (46.2) | 21 | (53.8) | ||||||
E6-positive and -negative expression in lung tumors evaluated by immunohistochemistry obtained from our previous reports. MiR-184 and Bcl-2 mRNA levels in lung tumors were determined by real-time PCR analysis. The median value of miR-184 (0.98) and Bcl-2 mRNA (1.23) in this study population was used as a cutoff point to divide patients into “low” and “high” subgroup.