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. 2016 Apr 7;7(22):32375–32393. doi: 10.18632/oncotarget.8632

Figure 8. G6PD is up-regulated in biopsies from human HCCs and correlates with metastatic status, poor prognosis and NQO1 mRNA levels.

Figure 8

A. G6PD mRNA levels in a validating cohort of biopsied human HCCs (n=59) and their peritumoural liver (PT). The levels of G6PD mRNA in healthy livers are also shown (left); *P < 0.05. B. Higher G6PD expression was significantly associated with high-grade (Edmonson III-IV, *P <0.05) and significantly correlated C. with metastasis formation; *P <0.05; D. Kaplan-Maier analysis showing decreased overall survival of HCC patients expressing high G6PD mRNA levels; P = 0.0173. E. Scatter-plot graphic showing a positive correlation between NQO1 and G6PD mRNA levels in HCC.