Table 2. ROC analysis and diagnostic performance of the four serine proteases based on serum MRM detection.

Proteins	AUC	Sensitivity	Specificity	p value
CELA1	0.83 (95%CI, 0.72-0.93)	60.0%	93.3%	<0.001
CEL2A	0.87 (95%CI, 0.78-0.96)	83.3%	80.0%	<0.001
CTRL	0.87 (95%CI, 0.79-0.96)	76.7%	86.7%	<0.001
TRY2	0.85 (95%CI, 0.75-0.94)	80.0%	76.7%	<0.001
CELA1&CEL2A	0.88 (95%CI, 0.80-0.97)	96.7%	66.7%	<0.001
CELA1&CTRL	0.90 (95%CI, 0.83-0.98)	90.0%	80.0%	<0.001
CELA1&TRY2	0.90 (95%CI, 0.83-0.98)	86.7%	80.0%	<0.001
CEL2A&CTRL	0.90 (95%CI, 0.83-0.98)	86.7%	80.0%	<0.001
CEL2A&TRY2	0.90 (95%CI, 0.83-0.98)	86.7%	80.0%	<0.001
CTRL&TRY2	0.89 (95%CI, 0.82-0.97)	83.3%	83.3%	<0.001
CELA1&CEL2A&CTRL	0.90 (95%CI, 0.83-0.98)	90.0%	80.0%	<0.001
CELA1&CEL2A&TRY2	0.89 (95%CI, 0.82-0.97)	73.3%	90.0%	<0.001
CELA1&CTRL&TRY2	0.89 (95%CI, 0.82-0.97)	83.3%	80.0%	<0.001
CEL2A&CTRL&TRY2	0.90 (95%CI, 0.83-0.97)	86.7%	80.0%	<0.001
CELA1&CEL2A&CTRL&TRY2	0.90 (95%CI, 0.83-0.98)	86.7%	83.3%	<0.001