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. 2016 Apr 13;7(22):32678–32694. doi: 10.18632/oncotarget.8724

Figure 6. MERTK inhibition with UNC1062 or MERTK knockdown decreases cell migration and invasion via RhoA.

Figure 6

A. Detroit 562 and HN cells were pretreated with 0.25 μM UNC1062 for 24 hours before assessing migration and invasion after further 48 hours. B. MERTK knockdown was induced in Detroit 562 cells before assessing migration and invasion after further 48 hours. C. Detroit 562 cells were treated with increasing amounts of UNC1062 or knockdown was induced using doxycycline before isolating proteins. D. HN cells were treated with increasing amounts of UNC1062 before isolating proteins. (A, B: two-tailed paired t-test, n=3, C, D: n=2, * p < 0.05, ** p < 0.01, *** p < 0.001).