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. 2016 Apr 26;7(22):32707–32722. doi: 10.18632/oncotarget.9017

Figure 7. Extracellular miR-1246 promotes cell proliferation and induces radioresistance via directly suppressing DR5 in bystander cells.

Figure 7

(A) The scheme of experiments. A549 cells were irradiated with 4 Gy X-rays or transfected with miR-1246 mimics, miR-1246 inhibitor and their control, respectively. Then its CM was collected to treat non-irradiated bystander cells for 48 h. (B) miR-1246 expressions in the bystander H446 cells treated with the CM from A549 cells as shown in Figure 7A. (C) Proliferations of H446 and A549 cells after 48 h of incubation with the active CM (ACM) from A549 cells or its control (CCM). (D) Clonogenic survival of irradiated H446 cells that were treated with the CM indicated above. (E) DR5 protein expression in the bystander H446 cells that were treated with the CM indicated above. Data were presented as means ± SEMs of three independent experiments (*P < 0.05, **P < 0.01).