Figure 1. Distribution of TP53 and PIK3CA mutations in early breast cancer.

(A) TP53 mutations were dispersed throughout the coding region but aggregated in the area coding for the DNA binding domain of the protein. (B) PIK3CA mutations were more common in the kinase domain. In the pies in A and B, the distribution of mutation types per gene is shown. fs: frameshift; indels: insertions/deletions.