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. 2016 Apr 26;7(22):32731–32753. doi: 10.18632/oncotarget.9022

Figure 2. TP53 and PIK3CA mutation characteristics according to tumor subtypes.

Figure 2

Mutations are described for presence / absence and domain specificity as indicated. TP53 mutations are compared for mutation types (missense, frameshift indels, nonsense). Y-axes have been truncated at 50%. Numbers per category are shown. Grey parts in bars: complementary to the colored category. All mutations and their characteristics were related to ER/PgR status. Helical, kinase: mutations in the corresponding domains of PIK3CA; fs-indels: frameshift insertions / deletions; TAD, oligo: TP53 transactivation and oligomerization domains.