Table 2. Genotype and allele frequencies of the DCC polymorphisms among the cases and controls and the associations with breast cancer risk.

Model	Genotype	Case (560)	Control (583)	OR (95% CI)†	P-value*
rs2229080  HWE = 0.07
Codominant	G/G	158 (28.2%)	212 (36.3%)	1.00 (reference)
	C/G	313 (55.9%)	296 (50.8%)	1.42 (1.09–1.84)	0.008
	CC	89 (15.9%)	75 (12.9%)	1.59 (1.10–2.31)	0.013
Dominant	GG	158 (28.2%)	212 (36.3%)	1.00 (reference)
	C/G-C/C	402 (71.8%)	371 (63.7%)	1.45 (1.13–1.87)	0.003
Recessive	G/G-C/G	471 (84.1%)	508 (87.1%)	1.00 (reference)
	C/C	89 (15.9%)	75 (12.9%)	1.28 (0.92–1.78)	0.144
Allele	G	629 (56.2%)	720 (61.7%)	1.00 (reference)
	C	491 (43.8%)	446 (38.3%)	1.26 (1.07–1.49)	0.007
rs7504990  HWE = 0.50
Codominant	C/C	346 (61.8%)	308 (52.8%)	1.00 (reference)
	C/T	181 (32.3%)	227 (38.9%)	0.71 (0.55–0.91)	0.007
	T/T	33 (5.9%)	48 (8.2%)	0.61 (0.38–0.98)	0.039
Dominant	C/C	346 (%)	308 (52.8%)	1.00 (reference)
	C/T-T/T	214 (38.2%)	275 (47.2%)	0.69 (0.55–0.88)	0.002
Recessive	C/C-C/T	527 (94.1%)	535 (91.8%)	1.00 (reference)
	T/T	33 (5.9%)	48 (8.2%)	0.70 (0.44–1.11)	0.123
Allele	C	873 (77.9%)	843 (72.3%)	1.00 (reference)
	T	247 (22.1%)	323 (27.7%)	0.74 (0.61–0.89)	0.002
rs4078288  HWE = 0.99
Codominant	A/A	307 (54.8%)	304 (52.1%)	1.00 (reference)
	G/A	212 (37.9%)	234 (40.1%)	0.90 (0.70–1.15)	0.384
	G/G	41 (7.3%)	45 (7.7%)	0.90 (0.57–1.42)	0.655
Dominant	A/A	307 (54.8%)	304 (52.1%)	1.00 (reference)
	G/A-G/G	253 (45.2%)	279 (47.9%)	0.90 (0.71–1.13)	0.364
Recessive	A/A-G/A	519 (92.7%)	538 (92.3%)	1.00 (reference)
	G/G	41 (7.3%)	45 (7.7%)	0.94 (0.61–1.47)	0.799
Allele	A	826 (73.8%)	842 (72.2%)	1.00 (reference)
	G	294 (26.2%)	324 (27.8%)	0.93 (0.77–1.11)	0.408

^*Two-sided χ² test for the distributions of genotype and allele frequencies.

^†Adjusted for age and body mass index.