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. 2016 Apr 20;7(22):33004–33015. doi: 10.18632/oncotarget.8844

Figure 3. LDE225 enhances the radiosensitivity by downregulating the activation of pAKT and NF-kB in HL60/ADR and HL60/RX cells.

Figure 3

A. Cells were treated with vehicle alone, radiation alone, LDE225 alone, and combination therapy (LDE225+radiation) respectively. The protein expression of Gli-1, AKT, pAKT, NF-kB, Rad51, BAK were analyzed by western blot. The quality of separation was monitored using GAPDH as mark B–I. and Histone H3 J, K. Each bar represents the mean ± SD. #, p<0.001 vs vehicle-treated control group or radiation group; *, p<0.01 vs vehicle-treated control group or radiation group **, p<0.001 vs radiation group; ***, p<0.01 vs vehicle-treated control group; &, p<0.001 vs vehicle-treated control group, radiation group, or LDE225 group. Abbreviation: RT, radiation.