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. 2016 Apr 20;7(22):33096–33110. doi: 10.18632/oncotarget.8861

Figure 1. NLRX1 Gene Expression is Significantly Dysregulated in Diverse Human Neoplasms.

Figure 1

A. A retrospective analysis of gene expression metadata from samples collected from human subjects revealed that NLRX1 expression was significantly dysregulated in a diverse range of cancer subtypes. Data shown were determined to be significant changes in NLRX1 expression between the tumor sample and either adjacent tissue from the same subject or a comparable tissue from an unaffected control subject based on the specific parameters established in each individual study. B-C. Macrophages from Nlrx1−/− mice rapidly proliferate and release increased cytokines associated with cell growth and migration. B) Bone marrow derived macrophages from Nlrx1−/− mice significantly expand under standard tissue culture conditions. C) Significant increases in Ccl2 (Monocyte Chemotactic Protein-1) and Csf3 (GCSF) gene expression were observed in Nlrx1−/− macrophages compared to wild type macrophages. Data are representative of 5 independent studies. *p<0.05.