Skip to main content
. 2016 Apr 20;7(22):33111–33124. doi: 10.18632/oncotarget.8880

Figure 1.

Figure 1

A. Characterization of the levels of phospho-Src in the CRC cell lines used in this study. Western blots were performed to measure p-Src, Src and p42/p44 MAPK protein levels. B. The cytotoxic effects of oxaliplatin directly correlate with activated Src protein levels. (a) IC50 values are separated in two differentiated groups by Src levels. (b) IC50 values without SD are grouped into a fall plot representation. C. Overexpression of c-Src in CRC cell lines induces activation of the pathway. Western blot analysis was performed to evaluate Src protein (anti-Src), the activated form of Src kinase (phosphorylated SrcY419), and p42/p44 Map kinase in CRC cell lines with normal endogenous expression of Src and overexpression of Src through stable transfection (T84 and SW480). D. Src inhibitor PP2 inhibits Src activity. Western blotting was performed to evaluate Src protein (anti-Src), the activated form of Src kinase (phosphorylated SrcY419), and p42/p44 Map kinase in CRC cell lines with normal endogenous expression of Src and overexpression of Src through stable transfection (T84 and SW480).