Table 2. Multivariate cox proportional hazard ratios for antidepressant use, overall survival, and PFS in ovarian cancer patients.
| Covariate | All ADs | SSRIs | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Progression | Death | Progression | Death | |||||||||
| HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
| Age | ||||||||||||
| (unit = 10 yrs) | 1.1 | 1.1-1.2 | 0.20 | 1.2 | 1.1-1.3 | <0.001 | 1.1 | 1.0-1.1 | 0.20 | 1.2 | 1.1-1.4 | <0.001 |
| Stage v I | ||||||||||||
| II | 1.6 | 0.9-2.9 | 0.09 | 1.1 | 0.5-2.4 | 0.83 | 1.6 | 0.9-2.9 | 0.09 | 1.1 | 0.5-2.5 | 0.80 |
| III | 3.9 | 2.5-6.1 | <0.001 | 3.2 | 1.8-5.9 | <0.001 | 4.0 | 2.5-6.2 | <0.001 | 3.3 | 1.8-5.9 | <0.001 |
| IV | 5.5 | 3.3-9.2 | <0.001 | 4.9 | 2.5-9.3 | <0.001 | 5.6 | 3.3-9.3 | <0.001 | 5.0 | 2.6-9.5 | <0.001 |
| RD v optimal | ||||||||||||
| Suboptimal | 1.9 | 1.6-2.3 | <0.001 | 2.1 | 1.7-2.6 | <0.001 | 2.0 | 1.6-2.4 | <0.001 | 2.1 | 1.7-2.6 | <0.001 |
| Grade v low | ||||||||||||
| High | 1.2 | 0.9-1.5 | 0.16 | 1.1 | 0.9-1.5 | 0.34 | 1.2 | 0.9-1.5 | 0.19 | 1.1 | 0.9-1.5 | 0.38 |
| Histol v other | ||||||||||||
| Serous | 1.1 | 0.9-1.4 | 0.27 | 1.0 | 0.8-1.4 | 0.73 | 1.1 | 0.9-1.4 | 0.26 | 1.0 | 0.8-1.4 | 0.77 |
| AD v non-use | ||||||||||||
| Use | 1.1 | 0.9-1.3 | 0.51 | 1.0 | 0.8-1.2 | 0.70 | 1.3 | 1.0-1.6 | 0.03 | 1.1 | 0.8-1.4 | 0.56 |
Abbreviations: AD, antidepressant; Histol, histology; PFS, progression-free survival; RD, residual disease; SSRI, selective serotonin-reuptake inhibitor; yrs, years.