Table 2. Uni- and multivariate analyses of pathophysiological parameters and Bik protein level in association with disease-free survival from Dataset-2.

Variable	Univariate (Cox)			Multivariate (Cox) - Stepwise
n=152	HR	95% CI	p	HR	95% CI	p
Age>50	0.36	0.12 to 1.10	0.074		ns
Tumor size >2 cm	1.18	0.44 to 3.09	0.743		ns
Mitotic grade	3.91	1.49 to 10.27	0.006	3.97	1.51 to 10.44	0.005
Vascular invasion	0.81	0.31 to 2.14	0.673		ns
ER status	0.37	0.14 to 0.99	0.050		ns
PR staus	0.40	0.16 to 1.05	0.062		ns
HER2 status	0.53	0.14 to 1.95	0.336		ns
Overall grade	3.29	1.07 to 10.09	0.037		ns
Menopausal status	0.58	0.21 to 1.56	0.277		ns
Bik	3.60	1.33 to 9.73	0.012	3.66	1.35 to 9.89	0.011

ns= non significant