Table 6. Antitumor Response Profile by Pearson Chi-square analysis.
| Factors | n | TOTAL (n=205) | H&NC (n=34) | GC (n=35) | ||||
|---|---|---|---|---|---|---|---|---|
| N(ORR)% | N(DCR)% | N(ORR)% | N(DCR)% | N(ORR)% | N(DCR)% | |||
| Total | 205 | 66(32.2) | 139(67.8) | 19(55.9) | 31(91.2) | 8(22.9) | 19(54.3) | |
| Sex | Male | 139 | 48(34.5) | 102(73.4) | 15(57.7) | 26(100.0) | 6(25.0) | 14(58.3) |
| Female | 66 | 18(27.3) | 37(56.1) | 4(50.0) | 5(62.5) | 2(18.2) | 5(45.5) | |
| p* | 0.445 | 0.002 | 0.187 | 0.005 | 0.193 | 0.028 | ||
| Age | <60y | 137 | 44(32.1) | 92(67.2) | 12(52.2) | 23(100.0) | 7(30.4) | 13(56.5) |
| ≥60y | 68 | 22(32.4) | 47(69.1) | 7(63.6) | 8(72.7) | 1(8.3) | 6(50.0) | |
| p* | 0.515 | 0.240 | 0.220 | 0.032 | 0.285 | 0.863 | ||
| Histology | ADC | 140 | 39(27.9) | 90(64.3) | 2 (100.0) | 2(100.0) | 8 (24.2) | 18(54.6) |
| non-ADC | 65 | 27(41.5) | 49(75.4) | 17 (53.1) | 29(90.6) | 0(0) | 1(50.0) | |
| p* | 0.128 | 0.283 | 0.432 | 0.902 | 0.367 | 0.471 | ||
| Treatment lines | 1st | 40 | 20(50.0) | 30(75.0) | 10(55.6) | 16(88.9) | 3(60.0) | 3(60.0) |
| 2nd | 81 | 26(32.1) | 57(70.4) | 4(44.4) | 8(88.9) | 4(19.0) | 13(61.9) | |
| 3rd | 41 | 13(31.7) | 25(61.0) | 3(100.0) | 3(100.0) | 1(12.5) | 3(37.5) | |
| >3rd | 43 | 7(16.3) | 27(62.8) | 2(50.0) | 4(100.0) | 0(0) | 0(0) | |
| p* | 0.036 | 0.702 | 0.683 | 0.937 | 0.208 | 0.345 | ||
| Nimotuzumab frequency | ≤6 | 73 | 17(23.3) | 39(53.4) | 6 (54.6) | 9(81.8) | 0(0) | 3(23.1) |
| >6 | 132 | 49(37.1) | 100(75.8) | 13 (56.5) | 22(95.7) | 8(36.4) | 16(72.7) | |
| p* | 0.050 | 0.004 | 0.85 | 0.335 | 0.004 | 0.006 | ||
| Nimotuzumab doses (mg/w) | ≤200 | 54 | 20(37.0) | 36(66.7) | 7 (53.9) | 11(84.6) | 1 (16.7) | 4(66.7) |
| >200 | 151 | 46(30.5) | 103(68.2) | 12 (57.1) | 20(95.2) | 7 (24.1) | 15(51.7) | |
| p* | 0.567 | 0.436 | 0.434 | 0.400 | 0.181 | 0.258 | ||
n: number of patients who have received at least one evaluation. p: statistical p value.
Bold text indicates statistically significant P-values (<0.05)
*
compared between two groups of each factor.