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. 2016 Mar 14;7(22):33461–33471. doi: 10.18632/oncotarget.8075

Figure 2. Proposed applications of the CRISPR/Cas9 system for brain tumor modeling.

Figure 2

Figure 2

Figure 2

Figure 2

Figure 2

Figure 2

Figure 2

A. shows the crystal structure of wt SpCas9 referred to Zhang et al [70]; B. is the model graphs of wt SpCas9, dSpCas9, SpCas9 variants, SaCas9 and Cpf1; C. D. E. F. display the processions of four different types of CRISPR-mediated genome editing including CRISPR knock out (CRISPR KO), CRISPR knock in (CRISPR KI), CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa), respectively; G. proposes four different sorts of CRISPR/Cas9 techniques are possibly involved in brain tumor modeling (BTM). CRISPR KO is presently successfully applied for BTM (as shown by solid arrow). We propose CRISPR KI, CRISPRi and CRISPRa are used for BTM (as shown by dotted arrows).