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. 2016 Oct 24;17(1):99. doi: 10.1186/s10194-016-0694-x

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 7 — Effect of sulforaphane pretreatment on front paw withdrawal and periorbital thresholds in NTG-induced rats. a The front paw withdrawal thresholds significantly decreased as early as 0.5 h and persisted for 4 h in the NTG group compared to those in the control group, whereas the thresholds significantly increased as early as 0.5 h and persisted for 4 h in the SFN plus NTG group compared to those in the H₂O plus NTG group. b The periorbital withdrawal thresholds also significantly decreased as early as 0.5 h and persisted for 4 h in the NTG group, while the thresholds significantly increased as early as 1 h and persisted for 4 h in the SFN plus NTG group compared to those in the H₂O plus NTG group. (*P < 0.05, **P < 0.01 for NTG vs control group, ^# P < 0.05 for SFN + NTG vs H₂O + NTG group. n = 6 per group)