Table 3.
Receiver operating characteristic curve reanalysis of deposited microarray expression data for DOCK9. EPHA4, and NPC2, to classify healthy donors (HD) and tuberculosis (TB) cases in cohorts from the UK, South Africa, Germany, and France.
| Study site (reference) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UK† (2) | South Africa¥ (2) | Germany (5) | UK/France (6) | ||||||
| Gene | n | Value [95% CI] | n | Value [95% CI] | n | Value [95% CI] | n | Value [95% CI] | |
| DOCK9 | AUC (HD vs. TB) | 0.79 [0.66–0.92] | 0.80 [0.66–0.95] | 0.53 [0.28–0.82] | 0.93 [0.84–1.0] | ||||
| Specificity (%) | 24 | 96 [79–100] | 31 | 97 [83–100] | 18 | 94 [73–100] | 52 | 96. [87–100] | |
| Sensitivity (%) | 34 | 15 [5–31] | 20 | 35 [15–59] | 8 | 13 [0.3–53] | 11 | 82 [48–98] | |
| EPHA4 | AUC (HD vs. TB) | 0.79 [0.66–0.91] | 0.92 [0.85–1.0] | 0.85 [0.69–1.0] | 0.90 [0.79–1.0] | ||||
| Specificity (%) | 24 | 96 [79–100] | 31 | 97 [83–100] | 18 | 94 [73–100] | 52 | 962 [87–100] | |
| Sensitivity (%) | 34 | 24 [11–41] | 20 | 75 [51–91] | 8 | 63 [25–92] | 11 | 55[23–83] | |
| NPC2 | AUC (HD vs. TB) | 0.95 [0.91–1.0] | 0.97 [0.93–1.0] | 0.99 [0.95–1.0] | 0.99 [0.97–1.0] | ||||
| Specificity (%) | 24 | 96 [79–100] | 31 | 97 [83–100] | 18 | 94 [73–100] | 52 | 96 [87–100] | |
| Sensitivity (%) | 34 | 82 [66–93] | 20 | 85 [66–97] | 8 | 100 [63–100] | 11 | 91 [58–100] | |
†Study population composed of immigrants from endemic countries or household contacts.
¥HD samples were not available; therefore, ROC analysis was performed comparing latently infected subjects and TB patients.