FIGURE 2.

Cell transformation and cell proliferation of tumor cell lines as mapped using the IPA software which demonstrates significant association with major cellular pathways. Here we have groups or complexes formed with cellular molecules including Rb, Skp2, CyclinD, the transcription factors E2F1, Tp73, Mdm2, Tp53, IRF4, Myc, HDAC1 and GMNN (Geminin), and kinases which include Aurora Kinase B, Pim1 and Gsk3B. We have also mapped the known regulation of these cellular antigens and their activities by the essential EBV latent antigens EBNA1, EBNA2, EBNA3C, and LMP1 for transformation and immortalization of EBV-infected cells leading to associated cancers.