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. 2016 Aug 25;12:189–195. doi: 10.1016/j.ebiom.2016.08.035

Table 1.

HCV Cascade of Care Definitions.

1. HCV Prevalence
2012 BC population: 4,542,508
The literature reports a range of 20–44% HCV undiagnosed.
Among linked cohort members alive on Dec. 31, 2012, there were 54,902 HCV Diagnosed (1.2% of the 2012 BC population)
From this number, we added 25% undiagnosed, or 73,203 anti-HCV positive persons living in BC in 2012 (1.6% of the 2012 BC population)
2. HCV Diagnoseda
On or before Dec. 31, 2012:
  • •

    a confirmed anti-HCV positive test

  • •

    a confirmed HCV RNA positive test

  • •

    an HCV genotype result

  • •

    dispensation of interferon-based antivirals

  • •

    a confirmed public health HCV case report

3. HCV RNA Tested
At least one HCV RNA (PCR) test on record on or before Dec. 31, 2012
3a. HCV RNA Negative
Among HCV Diagnosed individuals with no dispensation of interferon-based antivirals (untreated), the last HCV RNA test on record on or before Dec. 31, 2012 is negative. These individuals are considered not actively infected/non-viraemic
4. HCV Genotyped
At least one valid genotype test result on record on or before Dec. 31, 2012
5. Initiated HCV Antiviral Treatment
Dispensation, on or before Dec. 31, 2012, of interferon-based antivirals specific to HCV treatmentb
6. Estimated SVRc
Among treated individuals:
  • •

    in those with HCV RNA testing results between 12 and 52 weeks after the last drug dispensation on record, HCV RNA testing is persistently negative or the last two HCV RNA results are negative

  • •

    in those without HCV RNA testing results between 12 and 52 weeks after the last dispensation, HCV RNA testing results after 52 weeks are persistently negative

NB: 1361(16.0%) treated individuals lacked adequate HCV RNA data in the timeframe of interest to be assessed for SVR.

a

Earliest available laboratory testing data (1992), reportable disease data (1990), and drug dispensation data (2000).

b

Drug Information Number/Product Identification Number (DINPIN): 2254603, 2254638, 2254646, 2371448, 2371456, 2371464, 2371472, 2371553, 2370816, 2241159, 2239730, 2246030, 2246028, 2246029, 2246027, 2246026, 2253410, 2253429, 2254581.

c

HCV RNA data up to Dec. 31st, 2013 was included to allow assessment of SVR for 2012 treatment starts.