Fig. 3.

The mutational landscape of molecular subtypes of bladder cancer of fresh frozen bladder tumor samples in the TCGA cohort (n = 408). A. The proportion of bladder cancer cases with statistically significant levels of mutations (MutSig, false discovery rate < 0.05). B. Mutation types in molecular subtypes of bladder cancer classified according to their expression profiles of luminal and basal markers. C. The proportion of mutations for individual genes in luminal and basal subtypes of bladder cancer. The genes which show statistically significant difference (p < 0.05) in molecular subtypes are indicated by an asterisk. D. Mutation patterns of the FGFR3, ELF3, and NFE2L2 genes in luminal and basal cancers.