Fig. 3.

Intra-abscess application of DJK-5 impaired MRSA cutaneous injury. (a) Mice were injected with 3 mg/kg of DJK-5 or saline (control) via intra-abscess injection after subcutaneous infection with MRSA USA300. Abscess lesion sizes were measured using a caliper after 72 h, n = 12/group. (b) Bacterial enumeration from saline and DJK-5 intra-abscess-treated abscesses three days post-infection, n = 8 saline, n = 7 DJK-5. (c) Weight loss/gain of infected mice was assessed by measuring the mouse weights pre-infection and 72 h post-infection n = 12 saline, n = 11 DJK-5. (d) Representative Gram stain of saline and DJK-5 treated skin biopsies. (e) Hematoxylin and eosin stain of skin explants taken from saline and DJK-5 treated mice. Yellow arrows indicate suppurative myositis.