Table 1.
Recent bone graft prefabrication studies in small animal models.
| Reference/year | Animal model | IVB | Scaffold | Seed cells | Growth factor |
|---|---|---|---|---|---|
| Ersoy et al., 2015 | Rat | Periosteal flap | Bioactive glass or HA within a Gore-Tex pocket | None | None |
| Patel et al., 2015a | Mouse | Subcutaneous pocket | PCL | None | BMP-2 |
| Patel et al., 2015b | Mouse | Subcutaneous pocket | PCL | None | BMP-2 and EPO |
| Buehrer et al., 2015 | Rat | AVL between FVs | HA, β-TCP, and fibrin gel | MSCs | BMP-2 |
| Sathy et al., 2015a, Sathy et al., 2015b | Mouse | Subcutaneous pocket | PCL, HA, and gelatin | MSCs | None |
| Wu et al., 2015a | Mouse | Subcutaneous pocket | β-TCP and CHA | BMSCs | None |
| Han et al., 2014 | Rabbit | Tibial periosteal flap combined with AVB from SVs | β-TCP | BMSCs | None |
| Han and Dai, 2013 | Rabbit | Muscular membrane combined with AVB from SVs | β-TCP | BMP-2-transfected BMSCs | None |
| Nakamura et al., 2013 | Rat | AVB from SVs | Bone allografts | None | BMP-2 |
| Rodrigues et al., 2013 | Rat | AVB from SIEVs | Deep-frozen bone or lyophilized-demineralized bone | None | None |
| Yang et al., 2013 | Rat | AVB from SIEVs | nHA-PA 66 | Endothelial induced ADSCs | None |
| Cai et al., 2013 | Rabbit | AVB from FVs | Fibrin matrix within an inion membrane tube | None | BMP-2 |
| Scotti et al., 2013 | Mouse | Subcutaneous pocket | Type I collagen mesh | Chondrogenic induced MSCs | None |
| Koca et al., 2012 | Rabbit | AVB or subcutaneous pocket | Human bone allografts | None | None |
| Dong et al., 2012c | Rabbit | AVB from SVs | β-TCP within a titanium cage | BMSCs | None |
| Sever et al., 2012 | Rat | AVB from SIEVs | PCHC | BMSCs | VEGF |
| Dong et al., 2012b | Rabbit | AVB from SVs | β-TCP within a titanium cage | BMSCs and PRP | None |
| Dong et al., 2012a | Rabbit | AVL between FVs | Natural coral blocks wrapped with an ePTFE membrane | None | None |
| Arkudas et al., 2012 | Rat | AVL between FVs | HA/β-TCP/fibrin matrix | None | None |
| Rath et al., 2011 | Rat | AVL between facial vessels | PLDLLA-TCP-PCL | Osteoblasts | BMP-2 |
| Kloeters et al., 2011 | Rabbit | AVB from inguinal vessels | PBCB | Osteogenic induced ADSCs | None |
| Farrell et al., 2011 | Mouse | Subcutaneous pocket | Collagen-GAG scaffolds | Osteogenic or chondrogenic induced hMSCs | None |
| Binderman et al., 2011 | Rat | Subcutaneous pocket | DBM | None | None |
| Sever et al., 2010 | Rat | AVB from SIEVs | HA | BMSCs | None |
| Okuda et al., 2010 | Rat | Fascia flap pedicled on SIEVs | β-TCP | Osteogenic induced ADSCs | None |
| Yachouh et al., 2010 | Rabbit | Femur periosteal flap pedicled on the descending artery of the knee | Irradiated bone fragment | None | None |
| Wang et al., 2010 | Rabbit | AVB from FVs | β-TCP | MSCs | None |
| Dong et al., 2010 | Rabbit | AVL between FVs | Natural coral blocks wrapped with an ePTFE membrane | None | None |
| Chang et al., 2010 | Rabbit | AVB from FVs | HA and collagen gel breads wrapped with an ePTFE membrane | MSCs | None |
| Kamei et al., 2010 | Rabbit | Omentum flap wrapped periosteum free graft | None | None | None |
| Arkudas et al., 2010 | Rat | AVL between FVs | HA/β-TCP granula | None | VEGF165 and bFGF |
ADSC, adipose-derived stem cells; AVB, axial vascular bundle; AVL, arteriovenous loop; bFGF, basic fibroblast growth factor; BMP-2, bone morphogenetic protein 2; BMSCs, bone marrow mesenchymal stem cells; β-TCP, beta-tricalcium phosphate; CHA, coralline hydroxyapatite; DBM, demineralized bone matrix; ePTFE, expanded-polytetrafluoroethylene; EPO, erythropoietin; FVs: femoral vessels; HA, hydroxyapatite ceramic; MSCs, mesenchymal stem cells; nHA-PA 66, nano-hydroxyapatite-polyamide 66; PBCB, processed bovine cancellous bone; PCHC, porous calcium hydroxyapatite ceramic; PCL, poly-ε-caprolactone; PLDLLA, poly(l-lactide-co-d,l-lactide); SIEVs: superficial inferior epigastric vessels; SVs: saphenous vessels; VEGF, vascular endothelial growth factor.