The number of central events (panel A) and obstructive events (panel B) by night in monthly intervals before and after tamsulosin exposure (“off tamsulosin”, blue dashes) and during tamsulosin exposure (“on tamsulosin”, solid red diamonds [central events] or solid red circles [obstructive events]). The on-tamsulosin data points begin with the first dose of tamsulosin and, to accommodate the time needed to clear tamsulosin from the body, continue until four days after the final tamsulosin dose. The incidence of central events did not change with α1-adrenergic blockade while both the incidence and duration (not shown) of obstructive events increased markedly during tamsulosin exposure. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)