Fig. 2.

Exercise induces increased Nrf2 at the whole-cell level, but nuclear accumulation is attenuated in older adults. Nrf2 response to exercise in the whole cell [A] and nuclear fraction [B] of PBMCs. Values are means±SEM. Representative blots of changes in Nrf2 and loading control in young (Y) and older (O) are provided above the corresponding graphs. There was a significant main effect of time in fold change of whole-cell Nrf2 (P=0.003). Nuclear accumulation only increased significantly in the young, but not the older group (main effect of age, P=0.031). Reprinted from [45] with permission from Elsevier.