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. 2016 Oct 25;10:247. doi: 10.3389/fncel.2016.00247

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Copyright © 2016 Weng, Chen, Wang, Zhuang and Behnisch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increase in mEPSC frequency suggests a presynaptic origin of eEF2K-inhibition mediated potentiation. (A) Representative traces of whole-cell voltage-clamp recordings of mEPSCs before (gray) and during (black) drug application are depicted. Scale bar: 10 pA/2 s. (B) The histogram summarizes the distribution of mEPSC amplitudes before (gray bars) and during (black bars) drug application over all events of all recordings (n = 7). (C) The mean amplitude before (gray bar) and during (black bar) drug application do not differ significantly (n = 7; 7.6 ± 0.7 pA versus 7.8 ± 1.0 pA; ns: p = 0.94). (D) The histogram indicates the distribution of the inter-event intervals for before (gray) and during (black) drug application for all events of all neurons analyzed (n = 7). (E) The cumulative probability of inter-event intervals of mEPSCs before (gray) and during (black) drug application differs. Vertical dashed lines indicate the maximal values of the inter-event intervals before (gray) and during (black) drug application. (F) The mean mEPSC frequencies differ significantly (^∗p = 0.0148) before and during drug application (n = 7, 1.2 ± 0.4 Hz versus 2.0 ± 0.6 Hz).