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. 2016 Oct 25;10:247. doi: 10.3389/fncel.2016.00247

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Copyright © 2016 Weng, Chen, Wang, Zhuang and Behnisch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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eEF2K-inhibition mediated fEPSP-potentiation does not rely on CaMKII, PKC or PKA. (A) The schemata outlines the relation of kinases in the regulation of vesicle release. (B) Inhibition of CaMKII by KN-93 does not attenuate drug-induced potentiation (control: white circles = 6; 5 μM A-484954: black circles, n = 6; 20 μM KN-93: gray circles, n = 4). (C) The graph represents data of PKC inhibition experiments (gray circles: n = 4) in comparison to drug-free (control: white circles, n = 6) and A-484954 (black circles: n = 6) experiments. (D) Inhibition of PKA (KT5720: gray circles, n = 4) did not alter the time course of fEPSPs in comparison with experiments with the application of A-484954 alone (black circles, n = 6). The drug-induced potentiation remained significantly different from that in control experiments (white circles, n = 6). Black and gray horizontal lines represent the application period of A-484954 and inhibitors, respectively. Brackets enclose periods with significant differences (ns: p > 0.05) between groups as specified by the circles. fEPSP traces at time points 1 and 2 are depicted. Scale bars: 0.5 mV/10 ms.