Table 3.
Gene Up-Down Regulation During SBTx Rejection
| Increased | |||
|---|---|---|---|
| Gene | Fold Regulation (Rejection relative to No Rejection) | p-value | |
| 1 | CSF3 | 14.8 | 0.024 |
| 2 | CXCL5 | 13.2 | 0.049 |
| 3 | CXCL6 | 10.4 | 0.019 |
| 4 | CXCL10 | 9.4 | 0.044 |
| 5 | IL1R2 | 9.4 | 0.041 |
| 6 | CSF2 | 8.4 | 0.025 |
| 7 | SELE | 6.3 | 0.015 |
| 8 | CTLA4 | 6.1 | 0.042 |
| 9 | MMP9 | 5.4 | 0.020 |
| 10 | IFNG | 5.2 | 0.008 |
| 11 | MADCAM1 | 4.9 | 0.010 |
| 12 | BDKRB1 | 4.7 | 0.006 |
| 13 | CD80 | 4.6 | 0.020 |
| 14 | PLA2G7 | 4.2 | 0.031 |
| 15 | IL1RL1 | 3.9 | 0.023 |
| 16 | CCR4 | 3.9 | 0.022 |
| 17 | CCL2 | 3.7 | 0.012 |
| 18 | ICAM1 | 3.7 | 0.014 |
| 19 | PTAFR | 3.6 | 0.027 |
| 20 | TLR8 | 3.5 | 0.014 |
| 21 | OAS2 | 3.0 | 0.018 |
| 22 | ITGAM | 2.8 | 0.025 |
| 23 | ITGB2 | 2.6 | 0.017 |
| 24 | CD86 | 2.5 | 0.035 |
| 25 | TNFSF13B | 2.5 | 0.022 |
| 26 | IRAK2 | 2.4 | 0.032 |
| 27 | OASL | 2.3 | 0.033 |
| 28 | BDKRB2 | 2.2 | 0.043 |
| 29 | ISG15 | 2.2 | 0.043 |
| 30 | IFITM1 | 2.2 | 0.022 |
| 31 | RIPK2 | 2.1 | 0.044 |
| 32 | GBP1 | 2.1 | 0.047 |
| Not Significant | IL33 | 1.7 | 0.756 |
| Decreased | |||
| 1 | PPARA | −2.1 | 0.026 |
| 2 | ACE | −3.7 | 0.044 |
| 3 | IL5 | −4.6 | 0.021 |
| 4 | VIPR1 | −7.2 | 0.028 |