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. 2016 Oct 25;6:36050. doi: 10.1038/srep36050

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) A box plot showing the medians and ranges of normalized LMO2 mRNA levels in multiple tumors from the TCGA Pan-cancer dataset. The small circles represent the outliers. (B) A two-dimensional scatter plot along with box plot showing the medians and distribution of LMO2 mRNA levels in normal breast tissue and primary malignant breast tumors in the TCGA breast invasive carcinoma RNA_seq dataset (n = 1208). The means of the relative LMO2 mRNA level () and sample counts are marked in the plot. ***p < 0.001 (Student’s t-test). (C) A two-dimensional scatter plot and a box plot showing the medians and distribution of LMO2 mRNA levels in normal colorectal tissues and primary malignant colorectal tumors from the TCGA colorectal carcinoma RNA_seq dataset (n = 430). The mean relative LMO2 mRNA level () and sample counts are marked in the plot. ***p < 0.001 (Student’s t-test). (D) Representative images of LMO2 immunohistochemistry from normal breast tissue, primary breast invasive ductal carcinoma, normal colon tissue, and primary colon adenocarcinoma from clinical patient sample sets. Predominantly cytosolic LMO2 staining was observed in most tissues. (E) A stacked bar plot showing the distribution of LMO2 expression in normal tissues and primary malignant tumors in 169 breast tissue samples and 140 colorectal tissue samples. The sample count percentage in each group and Pearson χ² test p-values are marked in the plots.

Inline graphic — (A) A box plot showing the medians and ranges of normalized LMO2 mRNA levels in multiple tumors from the TCGA Pan-cancer dataset. The small circles represent the outliers. (B) A two-dimensional scatter plot along with box plot showing the medians and distribution of LMO2 mRNA levels in normal breast tissue and primary malignant breast tumors in the TCGA breast invasive carcinoma RNA_seq dataset (n = 1208). The means of the relative LMO2 mRNA level () and sample counts are marked in the plot. ***p < 0.001 (Student’s t-test). (C) A two-dimensional scatter plot and a box plot showing the medians and distribution of LMO2 mRNA levels in normal colorectal tissues and primary malignant colorectal tumors from the TCGA colorectal carcinoma RNA_seq dataset (n = 430). The mean relative LMO2 mRNA level () and sample counts are marked in the plot. ***p < 0.001 (Student’s t-test). (D) Representative images of LMO2 immunohistochemistry from normal breast tissue, primary breast invasive ductal carcinoma, normal colon tissue, and primary colon adenocarcinoma from clinical patient sample sets. Predominantly cytosolic LMO2 staining was observed in most tissues. (E) A stacked bar plot showing the distribution of LMO2 expression in normal tissues and primary malignant tumors in 169 breast tissue samples and 140 colorectal tissue samples. The sample count percentage in each group and Pearson χ² test p-values are marked in the plots.