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. 2016 Oct 25;6:35956. doi: 10.1038/srep35956

Figure 8. Model of how ADAMTS6 and ADAMTS10 can regulate cell and focal adhesions and alter deposition of fibrillin microfibril arrays by retinal epithelial cells.

Figure 8

In the presence of ADAMTS10, which down regulates ADAMTS6 gene expression, cells can form adherens and tight junctions, and focal adhesions, which together support the formation of ordered microfibril arrays by enhancing fibrillin-1 multimerization and the organisation of microfibrils within bundles. When ADAMTS10 is depleted, and ADAMTS6 is consequently enhanced, cell-cell junctions are lost and cell surface HS is reduced. Consequently, fibrillin-1 multimerization and microfibril formation are reduced, and bundles are disorganized. The cytoskeleton also becomes poorly arranged.