Table 2. Histology results according to cytology and HPV genotyping results*.
| Histologic result | Cervicitis (n=453) | LSIL (n=356) | HSIL | AIS (n=4) | Cancer (n=47) | Total (n=1,102) | |||
|---|---|---|---|---|---|---|---|---|---|
| CIN 2 (n=82) | CIN 3 (n=146) | Unclassified (n=14) | |||||||
| Cytology | |||||||||
| NILM | 265 (75.9) | 69 (19.8) | 5 (1.4) | 10 (2.9) | 0 | 0 | 0 | 349 | |
| ASCUS | 102 (51.3) | 82 (41.2) | 5 (2.5) | 9 (4.5) | 1 (0.5) | 0 | 0 | 199 | |
| AGC | 10 (47.6) | 4 (19.0) | 1 (4.8) | 1 (4.8) | 0 | 4 (19.0) | 1 (4.8) | 21 | |
| ASC-H | 14 (16.3) | 21 (24.4) | 18 (20.9) | 29 (33.7) | 3 (3.5) | 0 | 1 (1.2) | 86 | |
| LSIL | 55 (21.6) | 169 (66.3) | 17 (6.6) | 11 (4.3) | 3 (1.2) | 0 | 0 | 255 | |
| HSIL | 6 (3.9)† | 11 (7.2) | 36 (23.7) | 84 (55.3) | 7 (4.6) | 0 | 8 (5.3) | 152 | |
| Cancer | 1 (2.5)‡ | 0 | 0 | 2 (5.0) | 0 | 0 | 37 (92.5) | 40 | |
| HPV DNA chip | |||||||||
| HR-HPV (-) | 331 (63.1) | 154 (29.3) | 13 (2.5) | 16 (3.0) | 1 (0.2) | 0 | 10 (1.9) | 525 | |
| Non-16/18 HR-HPV (+) | 84 (24.3) | 146 (42.2) | 51 (14.7) | 48 (13.9) | 9 (2.6) | 0 | 8 (2.3) | 346 | |
| HPV-16/18 (+) | 38 (16.5) | 56 (24.2) | 18 (7.8) | 82 (35.5) | 4 (1.7) | 4 (1.7) | 29 (12.6) | 231 | |
Values are presented as number (%).
AIS, adenocarcinoma in situ; AGC, atypical glandular cells; ASCUS, atypical squamous cells of undetermined significance; ASC-H, atypical squamous cells cannot exclude HSIL; CIN, cervical intraepithelial neoplasia; HPV, human papillomavirus; HR, high-risk; HSIL, high grade squamous intraepithelial lesion; LSIL, low grade squamous intraepithelial lesion; NILM, negative intraepithelial lesion or malignancy.
*HR-HPV (+) includes HPV-16 (+) and/or HPV-18 (+) and/or 12 other non-16/18 HR-HPV (+); HPV-16/18 (+) includes HPV-16 (+) and/or HPV-18 (+), with or without other HPV genotypes (+); non-16/18 HR-HPV (+) includes HPV-16 (–) and HPV-18 (–), 12 other HR-HPV (+) with or without low-risk HPV (+) or 'HPV-other types' (+); HR-HPV (–) includes low-risk HPV (+) or 'HPV-other types' (+) or HPV (–); among all 1,102 cases, 113 cases were infected with multiple HPV genotypes, and they were classified as the group with a higher risk for its constituents; LSIL is a synonym for CIN 1, mild squamous dysplasia, flat condyloma, koilocytotic atypia or koilocytosis; HSIL includes CIN 2 or 3 or unclassified HSIL. †Out of these six cases, four cases were diagnosed as tic 3 after follow-up and re-biopsy; three were diagnosed as squamous cell carcinoma in re-biopsy after 5 months, 11 months, and 2 years; and one was diagnosed as CIN 3 in re-biopsy after 6 months. ‡After a review of this case, re-biopsy was recommended, but the patient was lost during follow-up.