Table 4. Age-adjusted odds ratio for ≥CIN 2 of each HR-HPV genotype*.
| Variable | Total | ≥CIN 2 | Odds ratio† | 95% CI | p-value |
|---|---|---|---|---|---|
| HPV-16 (+) | 150 | 97 (64.7) | 21.703 | 13.534-34.801 | <0.001 |
| HPV-18 (+) | 33 | 13 (39.4) | 8.03 | 3.690-17.474 | <0.001 |
| HPV-31 (+) | 20 | 11 (55.0) | 15.918 | 6.183-40.981 | <0.001 |
| HPV-33 (+) | 27 | 17 (63.0) | 18.819 | 7.984-44.356 | <0.001 |
| HPV-35 (+) | 13 | 8 (61.5) | 18.012 | 5.541-58.556 | <0.001 |
| HPV-39 (+) | 22 | 1 (4.5) | 0.621 | 0.081-4.764 | 0.647 |
| HPV-45 (+) | 4 | 3 (75.0) | 40.997 | 4.104-409.518 | 0.002 |
| HPV-51 (+) | 23 | 5 (21.7) | 3.353 | 1.174-9.578 | 0.024 |
| HPV-52 (+) | 44 | 19 (43.2) | 9.354 | 4.713-18.566 | 0.000 |
| HPV-56 (+) | 31 | 6 (19.4) | 2.739 | 1.042-7.200 | 0.041 |
| HPV-58 (+) | 50 | 21 (42.0) | 8.331 | 4.319-16.067 | <0.001 |
| HPV-59 (+) | 3 | 1 (33.3) | 7.117 | 0.621-81.616 | 0.115 |
| HPV-66 (+) | 21 | 2 (9.5) | 1.275 | 0.285-5.710 | 0.75 |
| HPV-68 (+) | 26 | 6 (23.1) | 3.481 | 1.305-9.285 | 0.013 |
| HR-HPV (-) | 522 | 40 (7.7) | - | - | |
| Total | 989 | 250 (25.3) | - | - |
Values are presented as number (%).
CIN, cervical intraepithelial neoplasia; HPV, human papillomavirus; HR, high-risk.
*HR-HPV (–), as a control, includes low-risk HPV (+) or 'HPV-other types' (+) or HPV (–). Multiple infection cases (n=113) were excluded for evaluation of each risk of HR-HPV genotype.
†Odds ratio, age-adjusted odds ratio for ≥CIN 2.