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. 2016 Mar 22;21(11):1633–1642. doi: 10.1038/mp.2016.19

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Copyright © 2016 Macmillan Publishers Limited, part of Springer Nature.

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(a) Design and participant flow of the SMART trial. (b) Summary of factor-based interactions. (c) Participants in any PRT group significantly improved on ADAS-Cog (lower scores are better) compared with non-PRT groups (RES × TIME, F(90)=4.1, *P<0.05, Y axis reversed). (d) Participants in any CCT group attenuated the decline in Memory domain compared with non-CCT groups (COG × TIME, F(90)=5.7, *P<0.02). Error bars represent 95% confidence interval. Intention-to-treat analyses controlled for age, sex and education. ADAS-Cog, Alzheimer's Disease Assessment Scale-Cognitive scale; CCT, computerized cognitive training; COG, cognitive training factor; MRI, magnetic resonance imaging; PRT, progressive resistance training; RES, progressive resistant training factor; SMART, Study of Mental Activity and Resistance Training.