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. 2016 Mar 22;21(11):1633–1642. doi: 10.1038/mp.2016.19

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Copyright © 2016 Macmillan Publishers Limited, part of Springer Nature.

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(a) Example of hippocampal manual tracing. (b) No significant FACTOR × TIME interactions were observed on hippocampal volume, although a trend was observed that PRT group exhibited less atrophy (F(75)=2.143, P=0.147). (c, d) Blue shows FIRST-generated hippocampal mesh. Brown shows areas of significant (P<0.05) RES × COG × TIME effects before multiple comparison correction, indicative of areas of relative spared atrophy in combined training in comparison with stand-alone training. No areas survived multiple-comparison correction. Error bars represent s.d. All analyses controlled for age, sex and education. CCT, computerized cognitive training; COG, cognitive training factor; FIRST, functional MRI of the brain (FMRIB)'s Integrated Registration and Segmentation Tool; PRT, progressive resistance training; RES, progressive resistant training factor.