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. 2016 Mar 22;21(11):1633–1642. doi: 10.1038/mp.2016.19

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Copyright © 2016 Macmillan Publishers Limited, part of Springer Nature.

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(a) PC seed and PC_FC map for cohort at baseline. (b) Spatial map of significant PC_FC RES × TIME interaction anterior cingulate cluster (P_FDR<0.05; see Supplementary Information for full set of results). (c) Graph of individual values shows that PRT training led to decreased PC–ACC functional connectivity compared with non-PRT training (F(67)=23.3, *P<0.001). (d) Scatterplot of individual change in PC–ACC functional connectivity was not related to change in memory domain performance (r=0.09, P=0.456, N=72) or ADAS-Cog (r=0.11, P=0.349; not shown). (e) HIP seed and HIP_FC map for cohort at baseline. (f) Spatial map of significant HIP_FC COG × TIME interaction in left superior frontal lobe cluster (sFTL; P_FDR<0.05; see Supplementary Information for full set of results). (g) Plot of individual values shows that any CCT training led to increased HIP–sFTL functional connectivity compared with non-CCT training (F(65)=6.1, *P=0.012). (h) Scatterplot shows that increased HIP–sFTL functional connectivity is positively correlated with improved overall memory performance (r=0.33, P=0.005, N=72). All group-based analyses controlled for age, sex and education. ACC, anterior cingulate cortex; ADAS-Cog, Alzheimer's Disease Assessment Scale-Cognitive scale; CCT, computerized cognitive training; COG, cognitive training factor; FC, functional connectivity; FDR, false discovery rate; HIP, hippocampus; PC, posterior cingulate; PRT, progressive resistance training; RES, progressive resistant training factor.